Lulu Attack EX (ルルアタックEX): ingredients, dose and warnings in English

Lulu Attack EX (ルルアタックEX) is sold in Japan as a designated class 2 medicine: the box reads 第②類医薬品. In 6 tablets (adult dose for 1 day): Tranexamic Acid 750 mg, Ibuprofen 450 mg, Clemastine Fumarate 1.34 mg, Bromhexine Hydrochloride 12 mg, dl-Methylephedrine Hydrochloride 60 mg, Dihydrocodeine Phosphate 24 mg and 2 more. The package insert sets the adult dose at 2 tablets, 3 times a day, for ages 15 and over.

Updated October 3, 2026

150mgIbuprofen per dose

2 tabletsAdult dose

3Doses a day

第②類医薬品 · Designated class 2要確認 · Shop checks first

What is in Lulu Attack EX

The package insert lists 8 active ingredients in 6 tablets (adult dose for 1 day). The middle column is how each one is written on the Japanese box.

Lulu Attack EX: active ingredients in 6 tablets (adult dose for 1 day), from the Japanese package insert
Ingredient	Name on the box	Amount
Tranexamic Acid	トラネキサム酸	750 mg
Ibuprofen	イブプロフェン	450 mg
Clemastine Fumarate1 mg as clemastine	クレマスチンフマル酸塩	1.34 mg
Bromhexine Hydrochloride	ブロムヘキシン塩酸塩	12 mg
dl-Methylephedrine Hydrochloride	dl-メチルエフェドリン塩酸塩	60 mg
Dihydrocodeine Phosphate	ジヒドロコデインリン酸塩	24 mg
Thiamine Nitrate	チアミン硝化物（ビタミンB1硝酸塩）	25 mg
Riboflavin	リボフラビン（ビタミンB2）	12 mg

Additives, as written on the package insert (Japanese)

トレハロース、セルロース、マクロゴール、クロスカルメロースNa、ポリビニルアルコール(部分けん化物)、無水ケイ酸、硬化油、ステアリン酸Mg、ヒプロメロース、酸化チタン、カルナウバロウ

The maker publishes an English package insert for LULU Attack EX: Daiichi Sankyo Healthcare: LULU Attack EX (English package insert). This page translates the current Japanese package insert on PMDA.

Source: PMDA (Pharmaceuticals and Medical Devices Agency) — ルルアタックEX: package insert (添付文書) · Daiichi Sankyo Healthcare — LULU Attack EX: English package insert

What the package insert lists it for

The approved wording of the Japanese package insert, translated. It is what the product is sold for, not advice on what to take.

Relief of the various symptoms of a cold (sore throat, fever, chills, headache, runny nose, blocked nose, sneezing, cough, phlegm, joint pain, muscle pain)

The dose, as written on the package insert

Translated line by line from the directions and dosage (用法・用量) section.

Ibuprofen per dose: 150 mg
Adult dose: 2 tablets
Doses a day: 3
Age: 15 and over

Adults (15 and over): take 2 tablets per dose, 3 times a day, after a meal, preferably within 30 minutes.
Under 15: Do not take.

Notes on the directions

1. Follow the directions and dosage exactly.
2. How to take out the tablets
Press the raised part of the PTP sheet containing the tablet firmly with your fingertip to break the aluminium foil on the back, then remove the tablet and take it. (Accidentally swallowing it as it is can lead to unexpected accidents, such as it piercing the mucous membrane of the oesophagus)

Do not

The package insert opens with what you must not do.

(If you do not follow these, your current symptoms may get worse, and side effects or accidents become more likely)

1. Do not take it if you are one of the following people.

(1) People who have had allergic symptoms caused by this medicine or its ingredients
(2) People who have developed asthma after taking this medicine, or other cold medicines or pain and fever medicines
(3) Children under 15
(4) Women within 12 weeks of their expected date of delivery

2. Do not use any of the following medicines while taking this medicine.

Other cold medicines, pain and fever medicines, sedatives, cough medicines, oral medicines containing antihistamines, etc. (oral medicines for rhinitis, motion sickness medicines, allergy medicines, etc.), oral medicines containing Tranexamic Acid

3. Do not drive or operate machinery after taking it. (Drowsiness etc. may occur)

4. Women who are breastfeeding: do not take this medicine, or avoid breastfeeding if you take it.

5. Do not drink alcohol before or after taking it.

6. Do not take it for more than 5 days.

7. Do not take an excessive amount.

Ask a doctor, pharmacist or registered salesperson

The package insert says to ask for advice in these cases.

1. If you are one of the following people, ask a doctor, pharmacist or registered salesperson for advice before taking it.

(1) People who are receiving treatment from a doctor or dentist
(2) Women who are pregnant or think they may be pregnant
(3) Older people
(4) People who have had allergic symptoms caused by medicines etc.
(5) People who have the following symptoms: high fever, difficulty urinating
(6) People who have been diagnosed with the following: thyroid dysfunction, diabetes, heart disease, high blood pressure, liver disease, kidney disease, glaucoma, systemic lupus erythematosus, mixed connective tissue disease, people who have blood clots (cerebral thrombosis, myocardial infarction, thrombophlebitis, etc.), people who are at risk of developing thrombosis, respiratory dysfunction, obstructive sleep apnoea syndrome, obesity
(7) People who have had the following diseases: gastric/duodenal ulcer, ulcerative colitis, Crohn's disease

2. If the following symptoms appear after taking it, they may be side effects, so stop taking it immediately and ask a doctor, pharmacist or registered salesperson for advice, taking this leaflet with you.

[Part of the body: symptoms]

Skin: rash/redness, itching, bruising
Digestive system: nausea/vomiting, loss of appetite, stomach discomfort, stomach pain, mouth ulcers, heartburn, heavy stomach, gastrointestinal bleeding, abdominal pain, diarrhoea, bloody stools
Nervous system: dizziness, excitement, convulsions
Circulatory system: palpitations
Respiratory system: shortness of breath
Urinary system: difficulty urinating
Other: blurred vision, ringing in the ears, oedema, nosebleeds, bleeding gums, bleeding that is hard to stop, bleeding, back pain, excessive drop in body temperature, the body feeling tired

In rare cases the following serious symptoms may occur. If they do, see a doctor immediately.

[Name of the condition: symptoms]

Shock (anaphylaxis): right after taking it, itchy skin, hives, hoarseness, sneezing, itchy throat, difficulty breathing, palpitations, clouding of consciousness, etc. appear.
Oculomucocutaneous syndrome (Stevens-Johnson syndrome), Toxic epidermal necrolysis: high fever, bloodshot eyes, eye discharge, sores on the lips, sore throat, widespread rash/redness on the skin, etc. continue or rapidly get worse.
Liver dysfunction: fever, itching, rash, jaundice (the skin and the whites of the eyes turn yellow), brown urine, tiredness all over the body, loss of appetite, etc. appear.
Kidney disorder: fever, rash, decreased amount of urine, oedema all over the body, tiredness all over the body, joint pain (aching joints), diarrhoea, etc. appear.
Aseptic meningitis: severe headache accompanied by a stiff neck, fever, nausea/vomiting, etc. appear. (Such symptoms have been reported especially often in people who are receiving treatment for systemic lupus erythematosus or mixed connective tissue disease)
Myocardial infarction: chest pain that feels like being squeezed, difficulty breathing, breaking out in a cold sweat.
Cerebrovascular disorder: reduced/lost consciousness, difficulty moving the arm and leg on one side, headache, vomiting, dizziness, difficulty speaking, difficulty getting words out, etc. appear suddenly.
Interstitial pneumonia: shortness of breath/difficulty breathing when climbing stairs or exerting yourself a little, dry cough, fever, etc. are seen, and these appear suddenly or continue.
Asthma: wheezing or whistling sounds when breathing, difficulty breathing, etc. appear.
Aplastic anaemia: bruises, nosebleeds, bleeding gums, fever, the skin and mucous membranes looking pale, a feeling of fatigue, palpitations, shortness of breath, feeling unwell and light-headed, blood in the urine, etc. appear.
Agranulocytosis: sudden high fever, chills, sore throat, etc. appear.
Respiratory depression: shortness of breath, difficulty breathing, etc. appear.

3. The following symptoms may appear after taking it, so if these symptoms continue or get worse, stop taking it and ask a doctor, pharmacist or registered salesperson for advice, taking this leaflet with you.

Constipation, dry mouth, drowsiness

4. If your symptoms do not improve after taking it 5 to 6 times, stop taking it and ask a doctor, pharmacist or registered salesperson for advice, taking this leaflet with you. (Especially when the fever continues for 3 days or more, or when the fever keeps coming back)

Other precautions

[Precautions related to the ingredients and amounts]
Urine may turn yellow due to the Riboflavin contained in this medicine.

Who can sell it in Japan

The Lulu Attack EX box carries the class 第②類医薬品, which decides who may sell it.

On the box: 第②類医薬品 (Designated class 2). The box reads 第2類医薬品 with the 2 in a square, or 第②類医薬品.
Who can sell it: A pharmacist or a registered salesperson may sell it.

要確認: the shop checks before selling this one.Lulu Attack EX contains Dihydrocodeine Phosphate and dl-Methylephedrine Hydrochloride. From 1 May 2026, medicines taken by mouth with these ingredients are designated abuse-prevention medicines (指定濫用防止医薬品).

Source: e-Gov law search (Digital Agency, Japan) — Pharmaceutical and Medical Device Act (医薬品医療機器等法), current text · e-Gov law search (Digital Agency, Japan) — Enforcement Regulations of the Pharmaceutical and Medical Device Act (施行規則), current text · Ministry of Health, Labour and Welfare — Designated class 2 medicines (指定第２類医薬品について) · Ministry of Health, Labour and Welfare — Designated abuse-prevention medicines, Notice No. 32 of 2026 (告示第32号) · Ministry of Health, Labour and Welfare — Quantity for designated abuse-prevention medicines, Notice No. 33 of 2026 (告示第33号) · Ministry of Health, Labour and Welfare — Selling designated abuse-prevention medicines (医薬発1226第16号, 26 December 2025) · Ministry of Health, Labour and Welfare — Q&A on selling designated abuse-prevention medicines (30 January 2026)

Taking it home

Lulu Attack EX contains Dihydrocodeine Phosphate. South Korea, Taiwan, mainland China and Hong Kong each have official rules on this ingredient.

Frequently asked questions

How much Ibuprofen is in Lulu Attack EX?

150 mg in a dose of 2 tablets, according to the Japanese package insert. The package insert lists 450 mg in 6 tablets (adult dose for 1 day).

How much Lulu Attack EX can an adult take in a day?

The package insert sets the adult dose at 2 tablets, 3 times a day.

Can children take Lulu Attack EX?

No. The package insert says it is not to be taken under 15.

Do I need a pharmacist to buy Lulu Attack EX?

Lulu Attack EX is a designated class 2 medicine (第②類医薬品). A pharmacist or a registered salesperson may sell it.

Why does the shop check before selling Lulu Attack EX?

It contains Dihydrocodeine Phosphate and dl-Methylephedrine Hydrochloride, two of the 8 ingredients that make a medicine taken by mouth a designated abuse-prevention medicine (指定濫用防止医薬品) from 1 May 2026. The shop gives the information in writing and checks what you have bought there and at other shops.

What is Lulu Attack EX called in Japanese?

ルルアタックEX. The Lulu Attack EX box also carries the class 第②類医薬品.