EVE A (イブA錠): ingredients, dose and warnings in English

EVE A (イブA錠) is sold in Japan as a designated class 2 medicine: the box reads 第②類医薬品. The maker writes the name in English as EVE A TABLETS. In 2 tablets: Ibuprofen 150 mg, Allylisopropylacetylurea 60 mg, Anhydrous Caffeine 80 mg. The package insert sets the adult dose at 2 tablets, up to 3 times a day, for ages 15 and over.

Updated October 3, 2026

150mgIbuprofen per dose

2 tabletsAdult dose

Up to 3Doses a day

第②類医薬品 · Designated class 2

What is in EVE A

The package insert lists 3 active ingredients in 2 tablets. The middle column is how each one is written on the Japanese box.

EVE A: active ingredients in 2 tablets, from the Japanese package insert
Ingredient	Name on the box	Amount
Ibuprofen	イブプロフェン	150 mg
Allylisopropylacetylurea	アリルイソプロピルアセチル尿素	60 mg
Anhydrous Caffeine	無水カフェイン	80 mg

Ibuprofen in Japan

Additives, as written on the package insert (Japanese)

クロスカルメロースNa、無水ケイ酸、セルロース、ヒドロキシプロピルセルロース、ヒプロメロース、マクロゴール、ステアリン酸Mg、タルク、酸化チタン

The maker publishes an English package insert for EVE A TABLETS: SSP: EVE A TABLETS (English package insert). This page translates the current Japanese package insert on PMDA.

Source: PMDA (Pharmaceuticals and Medical Devices Agency) — イブA錠: package insert (添付文書) · SSP — EVE A TABLETS: English package insert

What the package insert lists it for

The approved wording of the Japanese package insert, translated. It is what the product is sold for, not advice on what to take.

Relief of menstrual pain (period pain), headache, toothache, throat pain, joint pain, muscle pain, neuralgia, lower back pain, pain from stiff shoulders, pain after tooth extraction, pain from bruises, earache, pain from fractures, pain from sprains and pain from injuries
Reducing fever when you have chills/fever

The dose, as written on the package insert

Translated line by line from the directions and dosage (用法・用量) section.

Ibuprofen per dose: 150 mg
Adult dose: 2 tablets
Doses a day: Up to 3
Age: 15 and over

Take the following single dose up to 3 times a day, avoiding an empty stomach as far as possible, with water or lukewarm water. Take doses at least 4 hours apart.

Dose by age, as written on the package insert
Age	Single dose
Adults (15 and over)	2 tablets
Under 15	Do not take

Notes on the directions

(1) Follow the directions and dosage exactly.
(2) How to take out the tablets
Press the raised part of the PTP sheet containing the tablet firmly with your fingertip to break the aluminium foil on the back, then remove the tablet and take it. (Accidentally swallowing it as it is can lead to unexpected accidents, such as it piercing the mucous membrane of the oesophagus.)

Do not

The package insert opens with what you must not do.

(If you do not follow these, your current symptoms may get worse, and side effects or accidents become more likely.)

1. Do not take it if you are one of the following people

(1) People who have had allergic symptoms caused by this medicine or its ingredients.
(2) People who have developed asthma after taking this medicine, or other pain and fever medicines or cold medicines.
(3) Children under 15.
(4) Women within 12 weeks of their expected date of delivery.

2. Do not take any of the following medicines while taking this medicine

Other pain and fever medicines, cold medicines, sedatives, motion sickness medicines

3. Do not drive or operate machinery after taking it

(Drowsiness etc. may occur.)

4. Do not drink alcohol before or after taking it

5. Do not keep taking it for a long time

Ask a doctor, pharmacist or registered salesperson

The package insert says to ask for advice in these cases.

1. If you are one of the following people, ask a doctor, dentist, pharmacist or registered salesperson for advice before taking it

(1) People who are receiving treatment from a doctor or dentist.
(2) Women who are pregnant or think they may be pregnant.
(3) Women who are breastfeeding.
(4) Older people.
(5) People who have had allergic symptoms caused by medicines etc.
(6) People who have been diagnosed with the following. Heart disease, kidney disease, liver disease, systemic lupus erythematosus, mixed connective tissue disease
(7) People who have had the following diseases. Gastric/duodenal ulcer, ulcerative colitis, Crohn's disease

2. If the following symptoms appear after taking it, they may be side effects, so stop taking it immediately and ask a doctor, dentist, pharmacist or registered salesperson for advice, taking this leaflet with you

Possible side effects, by part of the body

Skin: rash/redness, itching, bruising
Digestive system: nausea/vomiting, loss of appetite, stomach discomfort, stomach pain, mouth ulcers, heartburn, heavy stomach, gastrointestinal bleeding, abdominal pain, diarrhoea, bloody stools
Nervous system: dizziness
Circulatory system: palpitations
Respiratory system: shortness of breath
Other: blurred vision, ringing in the ears, oedema, nosebleeds, bleeding gums, bleeding that is hard to stop, bleeding, back pain, excessive drop in body temperature, the body feeling tired

In rare cases the following serious symptoms may occur. If they do, see a doctor immediately.

Rare but serious symptoms: name and signs

Shock (anaphylaxis): right after taking it, itchy skin, hives, hoarseness, sneezing, itchy throat, difficulty breathing, palpitations, clouding of consciousness, etc. appear.
Oculomucocutaneous syndrome (Stevens-Johnson syndrome), Toxic epidermal necrolysis: high fever, bloodshot eyes, eye discharge, sores on the lips, sore throat, widespread rash/redness on the skin, etc. continue or rapidly get worse.
Liver dysfunction: fever, itching, rash, jaundice (the skin and the whites of the eyes turn yellow), brown urine, tiredness all over the body, loss of appetite, etc. appear.
Kidney disorder: fever, rash, decreased amount of urine, oedema all over the body, tiredness all over the body, joint pain (aching joints), diarrhoea, etc. appear.
Aseptic meningitis: severe headache accompanied by a stiff neck, fever, nausea/vomiting, etc. appear. (Such symptoms have been reported especially often in people who are receiving treatment for systemic lupus erythematosus or mixed connective tissue disease.)
Myocardial infarction: chest pain that feels like being squeezed, difficulty breathing, breaking out in a cold sweat.
Cerebrovascular disorder: reduced/lost consciousness, difficulty moving the arm and leg on one side, headache, vomiting, dizziness, difficulty speaking, difficulty getting words out, etc. appear suddenly.
Asthma: wheezing or whistling sounds when breathing, difficulty breathing, etc. appear.
Aplastic anaemia: bruises, nosebleeds, bleeding gums, fever, the skin and mucous membranes looking pale, a feeling of fatigue, palpitations, shortness of breath, feeling unwell and light-headed, blood in the urine, etc. appear.
Agranulocytosis: sudden high fever, chills, sore throat, etc. appear.

3. The following symptoms may appear after taking it, so if these symptoms continue or get worse, stop taking it and ask a doctor, pharmacist or registered salesperson for advice, taking this leaflet with you

Constipation, drowsiness

4. If your symptoms do not improve after taking it 5 to 6 times, stop taking it and ask a doctor, dentist, pharmacist or registered salesperson for advice, taking this leaflet with you

Who can sell it in Japan

The EVE A box carries the class 第②類医薬品, which decides who may sell it.

On the box: 第②類医薬品 (Designated class 2). The box reads 第2類医薬品 with the 2 in a square, or 第②類医薬品.
Who can sell it: A pharmacist or a registered salesperson may sell it.

The five classes on Japanese medicine boxes, side by side

Source: e-Gov law search (Digital Agency, Japan) — Pharmaceutical and Medical Device Act (医薬品医療機器等法), current text · e-Gov law search (Digital Agency, Japan) — Enforcement Regulations of the Pharmaceutical and Medical Device Act (施行規則), current text · Ministry of Health, Labour and Welfare — Designated class 2 medicines (指定第２類医薬品について)

Taking it home

What the official customs pages say about the ingredients in EVE A. Check them before you fly.

South Korea: The Korea Customs Service's press release of 17 July 2025 gives, as examples, Japanese painkillers containing the psychotropic drug allylisopropylacetylurea, US cold medicines containing dextromethorphan and supplements containing melatonin, and says these medicines and foods are banned from being brought into Korea. The package insert lists allylisopropylacetylurea (Allylisopropylacetylurea) at 60 mg in 2 tablets.

Korea Customs Service, press release, 17 July 2025 (original in Korean)□ 또한, 최근 「마약류 관리에 관한 법률」상 향정신성의약품 성분을 함유한 해외 감기약ㆍ진통제뿐만 아니라 효능과 안전성이 입증되지 않은 건강기능식품 등도 반입*되고 있으나, * 【예시】 (의약품) 향정신성의약품인 ‘알릴이소프로필아세틸요소’ 함유 일본산 진통제와 ‘덱스트로메트로판’ 함유 미국산 감기약 등, (건강기능식품) ‘멜라토닌’ 성분이 함유된 영양제 등 ㅇ 이러한 의약품 및 식품은 국내 반입이 금지되므로 해외에서 무심코 구입하여 가지고 오는 경우가 없도록 해외 여행자의 주의가 요구된다.Korea Customs Service

Taking Japanese medicine home: the limits in South Korea, Taiwan, mainland China and Hong Kong

Source: Korea Customs Service — Press release, 17 July 2025 (보도자료) · Korea Customs Service — Narcotics and psychotropic ingredients (마약류 성분 목록)

Frequently asked questions

How much Ibuprofen is in EVE A?

150 mg in a dose of 2 tablets, according to the Japanese package insert.

How much EVE A can an adult take in a day?

The package insert sets the adult dose at 2 tablets, up to 3 times a day. Doses are at least 4 hours apart.

Can children take EVE A?

No. The package insert says it is not to be taken under 15.

Do I need a pharmacist to buy EVE A?

EVE A is a designated class 2 medicine (第②類医薬品). A pharmacist or a registered salesperson may sell it.

What is EVE A called in Japanese?

イブA錠. The EVE A box also carries the class 第②類医薬品.