Sante FX Neo (サンテFXネオ): ingredients, dose and warnings in English

Sante FX Neo (サンテFXネオ) is sold in Japan as a class 2 medicine: the box reads 第2類医薬品. Active ingredients: Neostigmine Methylsulfate 0.005%, Aminoethylsulfonic Acid 1%, Potassium L-Aspartate 1%, Tetrahydrozoline Hydrochloride 0.05%, Chlorpheniramine Maleate 0.03%, ε-Aminocaproic Acid 1%. The package insert says: Put 2 to 3 drops in the eye per dose, 5 to 6 times a day.

Updated October 3, 2026

2 to 3 dropsPer use

5 to 6Times a day

第2類医薬品On the box

第2類医薬品 · Class 2

What is in Sante FX Neo

The package insert lists 6 active ingredients. The middle column is how each one is written on the Japanese box.

Sante FX Neo: active ingredients, from the Japanese package insert
Ingredient	Name on the box	Amount
Neostigmine Methylsulfate	ネオスチグミンメチル硫酸塩	0.005%
Aminoethylsulfonic Acid	アミノエチルスルホン酸(タウリン)	1%
Potassium L-Aspartate	L-アスパラギン酸カリウム	1%
Tetrahydrozoline Hydrochloride	塩酸テトラヒドロゾリン	0.05%
Chlorpheniramine Maleate	クロルフェニラミンマレイン酸塩	0.03%
ε-Aminocaproic Acid	イプシロン-アミノカプロン酸	1%

Additives, as written on the package insert (Japanese)

クロロブタノール,ベンザルコニウム塩化物,ホウ酸,d-ボルネオール,dl-カンフル,l-メントール,pH調節剤

The maker publishes an English package insert for Sante FX NEO: Santen Pharmaceutical: Sante FX NEO (English package insert). This page translates the current Japanese package insert on PMDA.

Source: PMDA (Pharmaceuticals and Medical Devices Agency) — サンテFXネオ: package insert (添付文書) · Santen Pharmaceutical — Sante FX NEO: English package insert

What the package insert lists it for

The approved wording of the Japanese package insert, translated. It is what the product is sold for, not advice on what to take.

Eye fatigue, redness of the conjunctiva, itchy eyes, prevention of eye disease (after swimming, when dust or sweat gets in the eyes, etc.), eye inflammation caused by ultraviolet rays or other light rays (snow blindness, etc.), blurred vision (when there is a lot of eye discharge, etc.), blepharitis (sores on the eyelids), discomfort when wearing hard contact lenses

The dose, as written on the package insert

Translated line by line from the directions and dosage (用法・用量) section.

Per use: 2 to 3 drops
Times a day: 5 to 6
On the box: 第2類医薬品

Put 2 to 3 drops in the eye per dose, 5 to 6 times a day.

Notes on the directions

Follow the precautions below.
(1) If used excessively, you may feel abnormal sensitivity to light, or it may actually cause bloodshot eyes.
(2) When letting children use it, have them use it under the guidance and supervision of a parent or guardian.
(3) Do not let the tip of the container touch your eye, eyelid or eyelashes (the solution may become contaminated or cloudy because eye discharge, germs, etc. get in). Also, do not use it if it has become cloudy.
(4) Do not use it while wearing soft contact lenses.
(5) Use it only as eye drops.

Ask a doctor, pharmacist or registered salesperson

The package insert says to ask for advice in these cases.

1. If you are one of the following people, ask a doctor, pharmacist or registered salesperson for advice before using it.

(1) People who are receiving treatment from a doctor
(2) People who have had allergic symptoms caused by medicines etc.
(3) People who have the following symptoms
Severe eye pain
(4) People who have been diagnosed with the following
Glaucoma

2. If the following symptoms appear after using it, they may be side effects, so stop using it immediately and ask a doctor, pharmacist or registered salesperson for advice, taking this leaflet with you.

Possible side effects, by part of the body

Skin: rash/redness, itching
Eyes: bloodshot eyes, itching, swelling, stinging pain

3. In the following cases, stop using it and ask a doctor, pharmacist or registered salesperson for advice, taking this leaflet with you.

(1) If the blurred vision does not improve
(2) If your symptoms do not improve after using it for 5 to 6 days

Who can sell it in Japan

The Sante FX Neo box carries the class 第2類医薬品, which decides who may sell it.

On the box: 第2類医薬品 (Class 2). The box reads 第2類医薬品.
Who can sell it: A pharmacist or a registered salesperson may sell it.

The five classes on Japanese medicine boxes, side by side

Source: e-Gov law search (Digital Agency, Japan) — Pharmaceutical and Medical Device Act (医薬品医療機器等法), current text · e-Gov law search (Digital Agency, Japan) — Enforcement Regulations of the Pharmaceutical and Medical Device Act (施行規則), current text

Taking it home

Taking Japanese medicine home: the limits in South Korea, Taiwan, mainland China and Hong Kong

Frequently asked questions

Do I need a pharmacist to buy Sante FX Neo?

Sante FX Neo is a class 2 medicine (第2類医薬品). A pharmacist or a registered salesperson may sell it.

What is Sante FX Neo called in Japanese?

サンテFXネオ. The Sante FX Neo box also carries the class 第2類医薬品.